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Bertucci Lab

Publications

Supramolecular
Nucleic Acid-based Organosilica Nanoparticles

J. Am. Chem. Soc. 2023, 145, 42, 22903-22912.

Synthetic CRISPR Networks Driven by Transcription Factors via DNA Translators

 J. Am. Chem. Soc. 2025, 147, 24, 21184–21193.

Protein-to-DNA Input Exchange for CRISPR-Cas-Based Detection of Proteases

     Anal. Chem. 2024, 96, 47, 18645–18654.

36. L. Capelli, S. Marzari, E. Spezzani, A. Bertucci*

Synthetic CRISPR Networks Driven by Transcription Factors via Structure-Switching DNA Translators

J. Am. Chem. Soc. 2025, 147, 24, 21184–21193.

35. I. Van Zundert, E. Spezzani, R. R. Brillas, L. Paffen, A. Yurchenko, T. FA de Greef, L. Albertazzi, A. Bertucci, Tania Patiño Padial.

Real‐Time Monitoring of DNA Origami‐Cell Interactions via Single Particle Tracking. 

Small 2025, 21, 40, 2502496.

Featured in the Inside Back Cover of Small

34. D. Di Lena, E. Sisti. E. Brass, E. Belforte, B. Marini, A. Porchetta, L. Squarcia. E. Da Pozzo, A. Bertucci*, R. Ippodrino*

Rapid, Single-Step Monitoring of Monoclonal Antibody Bioavailability by Using a TNF-α-Based Multiepitope DNA Nanoswitch

Anal. Chem. 2025, 97, 15, 8195–8201.

33. A. Tonelli, A. Tortone, A. Grazioli, F. Pasquali, M. Sozzi, A. Candiani, L. Capelli, A. Bertucci*

A Portable and Low-Cost Single Board Computer-Based Spectrophotometric Platform for Optical Analysis in the UV and Visible Range

Adv. Sens. Res. 2025, 4, 4, 2400163.

32. L. Capelli, F. Pedrini, A. C. Di Pede, N. Bagheri, S. Fortunati, M. Giannetto, M. Mattarozzi, R. Corradini, A. Porchetta, A. Bertucci*

Synthetic Protein-to-DNA Input Exchange for Protease Activity Detection Using CRISPR-Cas12a

Anal. Chem. 2024,  96, 47, 18645–18654.

31. S. Fortunati,  M. Giannetto, F. Pedrini, P. Nikolaou, G. Donofrio, A. Bertucci,* M. Careri.

A novel magnetic ligand-based assay for the electrochemical determination of BRD4

Talanta 2024, 279, 126577

30. S. Fortunati, M. Giannetto, C. Giliberti, M. Mattarozzi, A. Bertucci, M. Careri.

Magnetic Beads as Versatile Tools for Electrochemical Biosensing Platforms in Point‐of‐Care Testing

Anal. Sens. 2024, 4 (3), e202300062.

29. P. Picchetti, S. Volpi, M. Sancho-Albero, M. Rossetti, M.D. Dore, T. Trinh, F. Biedermann, M. Neri, A. Bertucci, A. Porchetta, R. Corradini, H. Sleiman, L. De Cola.

Supramolecular Nucleic Acid-Based Organosilica Nanoparticles Responsive to Physical and Biological Inputs.

J. Am. Chem. Soc. 2023, 145, 42, 22903-22912.

28. P. Picchetti, S. Volpi, M. Rossetti, M.D. Dore, T. Trinh, F. Biedermann, M. Neri, A. Bertucci, A. Porchetta, R. Corradini, H. Sleiman, L. De Cola.

Responsive Nucleic Acid-Based Organosilica Nanoparticles.

J. Am. Chem. Soc. 2023, 145, 42, 22896-22902.

Featured in the Front Cover of JACS

27. S. Fortunati, C. Giliberti, M. Giannetto, A. Bertucci, S. Capodaglio, E. Ricciardi, P. Giacomini, V. Bianchi, A. Boni, I. De Munari, R. Corradini, M. Careri.

A highly sensitive electrochemical magneto-genosensing assay for the specific detection of a single nucleotide variation in the KRAS oncogene in human plasma. 

Biosens. Bioelectron.: X 2023, 15, 100404.

26. M. Mattarozzi, E. Laski, A. Bertucci, M. Giannetto, F. Bianchi, C. Zoani, M. Careri.

Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue.

Anal. Bioanal. Chem. 2023, 415, 119-135.

25. S. Fortunati, F. Pedrini, E. Del Grosso, L. Baranda Pellejero, A. Bertucci.*

Design of Specific Nucleic Acid-Based Biosensors for Protein Binding Activity.

Anal. Sens. 2022, 2 (6), e202200037.

24. F. Curti, S. Fortunati, W. Knoll, M. Giannetto, R. Corradini, A. Bertucci,* M. Careri.

A Folding-Based Electrochemical Aptasensor for the Single-Step Detection of the SARS-CoV-2 Spike Protein.

ACS Appl. Mater. Interfaces. 2022, 14, 19204-19211.

23. S. Fortunati, I. Vasini, M. Giannetto, M. Mattarozzi, A. Porchetta, A. Bertucci,* M. Careri.

Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout.

Anal. Chem. 2022, 94, 5075-5083.

Featured in the Supplementary Cover of Analytical Chemistry

22. M. Mattarozzi, L. Toma, A. Bertucci, M. Giannetto, M. Careri.

Aptamer-based assays: strategies in the use of aptamers conjugated to magnetic micro-and nanobeads as recognition elements in food control.

Anal. Bioanal. Chem. 2022, 14, 63-74.

21. M. Neri, J. Kang, J.M. Zuidema, J. Gasparello, A. Finotti, R. Gambari, M.J. Sailor, A. Bertucci,* R. Corradini.

Tuning the Loading and Release Properties of MicroRNA-Silencing Porous Silicon Nanoparticles by Using Chemically Diverse Peptide Nucleic Acid Payloads.

ACS Biomater. Sci. Eng. 2022, 8, 4123-4131.

20. A. Bertucci,* A. Porchetta, E. Del Grosso, T. Patiño, A. Idili, F. Ricci.*

Protein-Controlled Actuation of Dynamic Nucleic Acid Networks by Using Synthetic DNA Translators.

Angew. Chem. Int. Ed. 2020, 59, 20577-20581.

Featured as “VIP Paper” in Angew. Chem. Int. Ed.

19. M. Rossetti,† A. Bertucci,† T. Patiño, L. Baranda Pellejero, A. Porchetta.

Programming DNA-based systems through effective molarity enforced by biomolecular confinement

Chem. Eur. J. 2020, 26, 9826-9834.

Featured in the Frontispiece of Chem. Eur. J.

18. A. Glab, A. Bertucci, F. Martino, M. Wojnilowicz, A. Amodio, M. Venanzi, F. Ricci, G. Forte, F. Caruso, F. Cavalieri.

Dissecting the intracellular signalling and fate of a DNA nanosensor by super resolution and quantitative microscopy.

Nanoscale 2020, 12, 15402-15143.

17. J.M. Zuidema, C.M. Dumont, J. Wang, W.M. Batchelor, Y. Lu, J. Kang, A. Bertucci, N.M. Ziebarth, L.D. Shea, M.J. Sailor.

Porous Silicon Nanoparticles Embedded in Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth.

Adv. Funct. Mater. 2020, 30, 2002560.

16. J. M. Zuidema,† A. Bertucci,† J. Kang, M. J. Sailor, F. Ricci.

Hybrid polymer/porous silicon nanofibers for loading and sustained release of synthetic DNA-based responsive devices.

Nanoscale 2020, 12, 2333-2339.

Included in the themed collection: 2020 Nanoscale HOT Article Collection

15. E. Piantanida, G. Alonci, A. Bertucci, L. De Cola.

Design of Nanocomposite Injectable Hydrogels for Minimally Invasive Surgery.

Acc. Chem. Res. 2019, 52, 2101-2112.

14. M. Rossetti, E. Del Grosso, S. Ranallo, D. Mariottini, A. Idili, A. Bertucci,* A. Porchetta.*

Programmable RNA-based systems for sensing and diagnostic applications.

Anal. Bioanal. Chem. 2019, 411, 4293-4302.

13. A. Bertucci, K-H. Kim, J. Kang, J.M. Zuidema, S. H. Lee, E.J. Kwon, D. Kim, S.B. Howell, F. Ricci, E. Ruoslahti, H-J. Jang, M.J. Sailor.

Tumor-targeting, microRNA-silencing porous silicon nanoparticles for ovarian cancer therapy.

ACS Appl. Mater. Interfaces 2019, 11, 23926-23937.

12. M. Wojnilowicz, A. Glab, A. Bertucci, F. Caruso, F. Cavalieri.

Super-resolution imaging of proton sponge-triggered rupture of endosomes and cytosolic release of small interfering RNA.

ACS Nano 2019, 13, 187-202

11. A. Bertucci, J. Guo, N. Oppmann, A. Glab, F. Ricci, F. Caruso, F. Cavalieri.

Probing transcription factor binding activity and downstream gene silencing in living cells with a DNA nanoswitch.

Nanoscale 2018, 10, 2034-2044

10. A. Bertucci, A. Porchetta, F. Ricci.

Antibody-templated assembly of an RNA mimic of Green Fluorescent Protein.

Anal. Chem. 2018, 90, 1049-1053.

Featured in the Front Cover of Analytical Chemistry

9.   E. J. Kwon, M. Skalak, A. Bertucci, G. Braun, F. Ricci, E. Ruoslahti, M.J. Sailor, S.N. Bhatia.

Porous silicon nanoparticle delivery of tandem peptide anti-infectives for the treatment of Pseudomonas aeruginosa lung infections.

Adv. Mater. 2017, 29, 1701527.

Featured in the Frontispiece of Advanced Materials.

Featured in MIT News, EurekAlert, PhysOrg, Science Daily, and other news outlets.

Featured in Science Translational Medicine as Editor’s Choice – “Resistance is Futile”, STM 9, 2017.

8. A. Manicardi,† A. Bertucci,† A. Rozzi, R. Corradini.

A bifunctional monomer for on-resin synthesis of polyfunctional PNAs and tailored induced-fit switching probes.

Org. Lett. 2016, 18, 5452-5455.

7. R. Castagna, A. Bertucci, E. A. Prasetyanto, M. Monticelli, D. V. Conca, M. Massetti, P. P. Sharma, F. Damin, M. Chiari, L. De Cola, R. Bertacco.

Reactive microcontact printing of DNA probes on (DMA-NAS-MAP) co-polymer-coated substrates for efficient hybridization platforms.

Langmuir 2016, 32, 3308-3313.

6. E. A. Prasetyanto, A. Bertucci, D. Septiadi, R. Corradini, P. Castro-Hartmann, L. De Cola.

Breakable Hybrid Organosilica Nanocapsules for Protein Delivery.

Angew. Chem. Int. Ed. 2016, 55, 3323-3327.

Highlighted as “Hot Paper” and featured in the Inside Cover of Angew. Chem. Int. Ed.

See also “Disintegratable core/shell silica particles for encapsulating and releasing bioactive macromolecules” US Patent US10821082B2

5. A. Bertucci, E.A. Prasetyanto, D. Septiadi, A. Manicardi, E. Brognara, R. Gambari, R. Corradini, L. De Cola.

Combined delivery of temozolomide and anti-miR221 PNA using mesoporous silica nanoparticles induces apoptosis in resistant glioma cells.

Small 2015, 11, 5687-56

4. A. Bertucci, A. Candiani, S. Giannetti, A. Manicardi, A. M. Cucinotta, G. Spoto, M. Konstantaki, S. Pissadakis, S. Selleri, R. Corradini.

Detection of unamplified genomic DNA by a PNA-based microstructured optical fiber (MOF) Bragg-grating optofluidic system.

Biosens. Bioelectron. 2015, 63, 248-254.

3. A. Bertucci, H. Lülf, D. Septiadi, A. Manicardi, R. Corradini, L. De Cola.

Intracellular delivery of Peptide Nucleic Acid and organic molecules using zeolite-L nanocrystals.

Adv. Health. Mater. 2014, 3, 1812-1817.

2. H. Lülf, A. Bertucci, D. Septiadi, R. Corradini, L. De Cola.

Multifunctional inorganic nanocontainer for DNA and drug delivery into living cells.

Chem. Eur. J. 2014, 20, 10900-10904.

Featured in the Front Cover of Chemistry – A European Journal.

1. A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, S. Selleri.

Label- free DNA bionsensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating.

J. Biomed. Opt. 2013, 18, 057004.

Patents

1. L. De Cola, E. A. Prasetyanto, A. Bertucci, D. Septiady. Disintegratable core/shell silica particles for encapsulating and releasing bioactive macromolecules. US10821082B2, EP3154521B1, CN106456454B. 2020

Book Chapters

2. A. Bertucci, S. Silvestrini, R. Corradini, L. De Cola. Loading of PNA and other molecular payloads in inorganic nanostructures for theranostics. DNA Nanotechnology, Humana Press, New York, NY, USA, 2018.

1. A. Bertucci, A. Manicardi, R. Corradini. Advanced Molecular Probes for Sequence-Specific DNA Recognition. Detection of non-amplified Genomic DNA, G. Spoto, R. Corradini Eds., Springer, Dordrecht, Netherlands, 2012.